A higher body mass index (BMI) and waist circumference are associated with an increased risk of aggressive prostate cancer, according to a study of nearly 150,000 men from 8 European countries.
This analysis of the European Prospective Investigation Into Cancer and Nutrition (EPIC) was performed by Aurora Pérez-Cornago, PhD, a nutritional epidemiologist in the cancer epidemiology unit at the University of Oxford in England, and her colleagues. They presented their findings at the 2016 European Obesity Summit, which was held June 1–4 in Gothenburg, Sweden.
To date, evidence for the association of body size and obesity with prostate cancer risk has been unclear. Dr. Pérez-Cornago and her team investigated the associations between various body measurements at baseline and risk of prostate cancer incidence. They focused on tumor stage and grade as well as mortality. The participants included 141,896 men with a mean age of 52 years from Italy, Spain, the United Kingdom, the Netherlands, Greece, Germany, Sweden, and Denmark. Data were adjusted for education level, smoking, marital status, diabetes, and physical activity. Specifically, investigators focused on high-grade cancers and those that resulted in death.
Men with a higher BMI and waist circumference had an increased risk of more aggressive, high-grade prostate cancer (10% increased risk for every 5 kg/ m2 increase in BMI and 13% increased risk for every 10-cm increase in waist circumference). Moreover, a 14% higher risk for fatal prostate cancer was observed for every 5 kg/m2 increase in BMI along with an 18% increased risk for every 10 cm of additional waist circumference.
Story from Cancer Journal